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KMID : 0984920090110020118
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Journal of Skin Barrier Research
2009 Volume.11 No. 2 p.118 ~ p.118
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The role of NHE1 in the regulation of epidermal antimicrobial expression
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Kim Hyun-Jung
Jeong Se-Kyoo
Kim Ji-Min
Jeong Min-Kyung
Lee Seung-Hun
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Abstract
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The ‘acid mantle’ of the stratum corneum seems to be important for both permeability barrier formation and cutaneous antimicrobial defense. However, the origin of the acidic pH, measurable on the skin surface, remains still unfolding. The Na+/H+ antiporter (NHE1) is an essential endogenous pathway responsible for stratum corneum (SC) acidification and amiloride. We examined the decreased expression of NHE1 in chronic atopic dermatitis skin lesion and normal
expression on psoriasis. The nonselective inhibitor of NHE1, was effective for disruption of the normal skin barrier function. Recent studies have shown the co-regulation of permeability and antimicrobial barriers. Our previous study showed that the negative effect of the amiloride on the expression of antimicrobial peptides, which is co-related to various epidermal barrier functions , in human keratinocytes. We also evaluated the NHE1 inhibitiory effect on the down regulation of cytokine induced AMP expression. Our study suggested the importance of abnormal skin surface pH and decreased expression of AMP mediated by NHE1 in atopic dermatitis which is the representative highly infected condition.
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KEYWORD
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Acid mantle, Permeability barrier, Antimicrobial defense, Na/H antiporter
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